IMMUNOTHERAPY

Immunotherapy is the treatment Medibiologica offers to stimulate the immune system to fight cancer and other chronic diseases. Its beneficial effects include:

  • Stimulation of the antitumor response of the body by increasing tumor killer cells (Natural Killer).
  • It acts directly on tumors as destructive agent.
  • Stops mechanisms decreased immune response in the body.
  • Alter tumor cells, making them more susceptible to the immune system.
  • Stops or slows the growth and reproduction of cancer cells.
  • Increase the body’s tolerance to chemotherapy and radiation.

Treatment Phases

Our protocol is a treatment lasting three weeks, which consists of three phases:

1. DETOXIFICATION: The first phase is the detoxification process highly recommended especially for patients who have undergone aggressive treatments such as surgery, radiation and chemotherapy, combined with poor diet and environmental factors that may be weakening the immune system, making the process of fighting harder the illness. Usually this phase lasts a week and is done through intravenous treatments with high content of vitamins and minerals as well as ozone therapy that helps revitalize cells and tissue, according to the patient’s needs and condition. All this is complemented with a special diet designed for the patient that helps cleanse the body and receiving treatments are most effective.

2. IMMUNOTHERAPY. The second phase is more complex, as it enters the process of immunotherapy, comprising the application of different cells, each with dose and number of specific applications according to the patient’s condition. The cells applied are:

  • LAK Cells: Interleukins activated killer cells, also known as LAK cells are lymphocytes in the presence of IL-2 are stimulated to kill cancer cells. These lymphocytes are one of the five types of white blood cells, or leucocytes circulating in the blood and play an integral role in the body’s defenses. Cultivation of the lymphocytes with interleukin-2 gives rise to cytotoxic cells against cancer cells that act.

  • Natural Killer Cells: In therapy with killer cells, some of the cells themselves (a type of white blood cells) from a patient with cancer is removed. In the laboratory, the lymphocytes are exposed to a substance called interleukin-2 (growth factor Lymphocyte-T) to create (NK) activated killer cells lymphokine, which are injected back into the person intravenously. These cells have greater capacity than natural body cells to detect and kill cancer cells. NK CD56 + cells are obtained from peripheral blood, these are selected, activated with IL-21 and expanded, and preferably are used when many tumor burden exists, when the level of neoplastic cells circulating is more than 30% of total nucleated cells obtained, or when the patient has Hepatitis B, C, or mainly Lyme disease. The number of concentrates depends on the program of each patient. Applying them is intravenous.

  • Dendritic Cells: Dendritic cells (DC) are cells of highly specialized antigen present, which play a key role in immune reactions throughout the body, are responsible for identifying pathogens such as viruses, bacteria, fungi and malignant cells, present as identifying markers (antigens) in specific T cells, which then multiply and attack only diseased cells and not healthy cells.

    These cells are obtained by extraction from peripheral blood, and subsequently in the laboratory, Extracorporeal Photopheresis is performed for the blood to pass through an ultraviolet light chamber, which reports a huge immunostimulatory effect. In the separator cells, white blood cells such as monocytes and lymphocytes are removed (collected) from the blood returning to the body in a closed circuit. The collected monocytes are grown outside the body becoming active dendritic cells. When these potent dendritic cells are reinfused to the body they will have the ability to invoke an antitumor immune response. At the same time, in case of rejection or autoimmunity, the newly converted dendritic cells are capable of suspending (cancel) attacks against transplanted organs or tissues of the patient.

    Doses and the time interval depend on the patient’s response to treatment and overall condition. Side effects that some patients experience include an increase in body temperature for several hours, pain or tenderness in the tumor area for several days.

3. MAINTENANCE. The third and final phase of maintenance treatment in which the patient this phase takes home with some tumor vaccines so that they are applied according to the physician. These vaccines work in a complex way in the levels of cellular and humoral immunity mediated immunity and stimulate the formation and activation of helper T cells are cultured from the patient’s blood that represents its own internal environment, which is unique, and its preparation has stages that favor the development of antigen peptides and other immunogenic compounds that help increase immune functions of the body.

The vaccine is sterile as it is prepared from the blood of the patient, the side effects that are typically associated with other procedures are not experienced in this treatment, except for a small increase in temperature, fatigue, and for a period of 6 to 48 hours, some tenderness in the tumor area after the treatment administered. They have duration of 6 months at a temperature of 6 ° C (normal cooling), the application is 10 days and the number of vials will depend on the patient’s condition and the basic treatment of each.

Cytokines

Cytokines (from Cito “cell” and – Kinos “movement”) are proteins, peptides or glycoproteins and are substances that are secreted by specific cells of the immune system. It is they who are responsible for intercellular communication and activation, and therefore have an effect on other cells. They can work both locally and remotely to enhance or suppress immunity. In cancer treatment, cytokines are generally used to improve immunity. The term “cytokine” refers to the immuno-modulating agents such as interleukins, interferons, tumor necrosis factor, granulocyte colony-stimulating factor and macrophage. These medicines are also called biologic response modifiers.

Experience has shown that a comprehensive immune therapy, causes inflammation of the connective tissue with its cytokine cascade, and may increase activation, mobilization, and maturation of dendritic cells and behold the effectiveness of vaccines.